Synthesis and Biological Investigation of 1,2,4-Triazolo[4,3-a]azines as Potential HSF1 Inductors

Abstract Derivatives of fused 1,2,4-triazines containing heterocyclic and metallocene fragments were obtained by one-pot oxidative cyclization hydrazones in the presence hypervalent iodine(III) reagents. For 1,2,4-triazolo[4,3-a]azines, ability to activate HSF1 was investigated. The compounds shown increase degree activation. It that can be used induce Hsp70 expression decrease extent mutant HTT aggregate formation.